| 1. Identity statement | ||||
| Reference Type | Journal Article | |||
| Site | mtc-m21d.sid.inpe.br | |||
| Holder Code | isadg {BR SPINPE} ibi 8JMKD3MGPCW/3DT298S | |||
| Identifier | 8JMKD3MGP3W34T/45D5278 | |||
| Repository | sid.inpe.br/mtc-m21d/2021/09.07.15.19 (restricted access) | |||
| Last Update | 2021:09.07.15.19.06 (UTC) simone | |||
| Metadata Repository | sid.inpe.br/mtc-m21d/2021/09.07.15.19.06 | |||
| Metadata Last Update | 2024:05.08.19.58.09 (UTC) simone | |||
| DOI | 10.1007/s10856-021-06596-6 | |||
| ISSN | 0957-4530 | |||
| Citation Key | WacheskSeSaTrLoMa:2021:ViBiDi | |||
| Title | In vivo biocompatibility of diamond-like carbon films containing TiO2 nanoparticles for biomedical applications  | |||
| Year | 2021 | |||
| Month | Sept. | |||
| Access Date | 2024, May 08 | |||
| Type of Work | journal article | |||
| Secondary Type | PRE PI | |||
| Number of Files | 1 | |||
| Size | 1898 KiB | |||
| 2. Context | ||||
| Author | 1 Wachesk, C. C. 2 Seabra, S. H. 3 Santos, T. A. T. dos 4 Trava-Airoldi, Vladimir Jesus 5 Lobo, Anderson de Oliveira 6 Marciano, F. R. | |||
| ORCID | 1 0000-0001-7740-8766 | |||
| Group | 1 2 3 4 COPDT-CGIP-INPE-MCTI-GOV-BR | |||
| Affiliation | 1 Universidade Federal de São Paulo (UNIFESP) 2 Universidade Estadual da Zona Oeste (UEZO) 3 Universidade Estadual da Zona Oeste (UEZO) 4 Instituto Nacional de Pesquisas Espaciais (INPE) 5 Universidade Federal do Piaui (UFPI) 6 Universidade Federal do Piaui (UFPI) | |||
| Author e-Mail Address | 1 2 3 4 5 6 marciano@ufpi.edu.br | |||
| Journal | Journal of Materials Science: Materials in Medicine | |||
| Volume | 32 | |||
| Number | 9 | |||
| Pages | e117 | |||
| Secondary Mark | A1_MATERIAIS A1_INTERDISCIPLINAR A1_ENGENHARIAS_IV A1_ENGENHARIAS_II A2_ODONTOLOGIA A2_MEDICINA_VETERINÁRIA A2_ARQUITETURA_E_URBANISMO B1_QUÍMICA B1_MEDICINA_II B1_MEDICINA_I B1_FARMÁCIA B1_ENGENHARIAS_III B1_CIÊNCIAS_BIOLÓGICAS_II B1_CIÊNCIAS_BIOLÓGICAS_I B1_BIOTECNOLOGIA B1_ASTRONOMIA_/_FÍSICA B2_EDUCAÇÃO_FÍSICA B2_CIÊNCIAS_BIOLÓGICAS_III C_CIÊNCIA_DE_ALIMENTOS | |||
| History (UTC) | 2021-09-07 15:19:06 :: simone -> administrator :: 2021-09-07 15:19:06 :: administrator -> simone :: 2021 2021-09-07 15:20:48 :: simone -> administrator :: 2021 2022-04-03 23:14:04 :: administrator -> simone :: 2021 | |||
| 3. Content and structure | ||||
| Is the master or a copy? | is the master | |||
| Content Stage | completed | |||
| Transferable | 1 | |||
| Content Type | External Contribution | |||
| Version Type | publisher | |||
| Abstract | Hybrid diamond-like carbon (DLC) with incorporated titanium dioxide (TiO2) nanoparticle coatings have low friction coefficient, high wear resistance, high hardness, biocompatibility, and high chemical stability. They could be employed to modify biomedical alloys surfaces for numerous applications in biomedical engineering. Here we investigate for the first time the in vivo inflammatory process of DLC coatings with incorporated TiO2 nanoparticles. TiO2-DLC films were grown on AISI 316 stainless-steel substrates using plasma-enhanced chemical vapor deposition. The coated substrates were implanted in CF1 mice peritoneum. The in vivo cytotoxicity and biocompatibility of the samples were analyzed from macrophage lavage. Analysis in the first weeks after implantation could be helpful to evaluate the acute cytotoxicity generated after a possible inflammatory process. The in vivo results showed no inflammatory process. A significant increase in nitric oxide production on the uncoated substrates was confirmed through cytometry, and the coated substrates demonstrated biocompatibility. The presence of TiO2 nanoparticles enhanced the wound healing activity, due to their astringent and antimicrobial properties. DLC and TiO2-DLC coatings were considered biocompatible, and the presence of TiO2 nanoparticles reduced the inflammatory reactions, increasing DLC biocompatibility. | |||
| Area | FISMAT | |||
| doc Directory Content | access | |||
| source Directory Content | there are no files | |||
| agreement Directory Content |
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| 4. Conditions of access and use | ||||
| Language | en | |||
| Target File | washesc_in vivo.pdf | |||
| User Group | simone | |||
| Reader Group | administrator simone | |||
| Visibility | shown | |||
| Archiving Policy | denypublisher denyfinaldraft12 | |||
| Read Permission | deny from all and allow from 150.163 | |||
| Update Permission | not transferred | |||
| 5. Allied materials | ||||
| Next Higher Units | 8JMKD3MGPCW/46KUES5 | |||
| Citing Item List | sid.inpe.br/bibdigital/2022/04.03.23.11 3 | |||
| Dissemination | WEBSCI; PORTALCAPES; COMPENDEX. | |||
| Host Collection | urlib.net/www/2021/06.04.03.40 | |||
| 6. Notes | ||||
| Empty Fields | alternatejournal archivist callnumber copyholder copyright creatorhistory descriptionlevel e-mailaddress format isbn keywords label lineage mark mirrorrepository nextedition notes parameterlist parentrepositories previousedition previouslowerunit progress project resumeid rightsholder schedulinginformation secondarydate secondarykey session shorttitle sponsor subject tertiarymark tertiarytype url | |||
| 7. Description control | ||||
| e-Mail (login) | simone | |||
| update | ||||